GROWTH HORMONE/ HGH/ANTIAGING AND SPORTS

 

Thomas Perls MD, MPH, FACP

 
 
 

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Side Effects

Are there any risks to taking growth hormone?

(from the Mayo Clinic: http://www.mayoclinic.com/health/growth-hormone/HA00030) Taking growth hormone can cause a number of side effects, including:
  • Swelling in your arms and legs
  • Arthritis-like symptoms
  • Carpal tunnel symptoms
  • Headaches
  • Bloating
  • Muscle pain
  • Diabetes
  • Abnormal growth of bones and internal organs
  • Hardening of the arteries
  • High blood pressure
  • Some evidence shows that side effects of growth hormone may be more likely in people over the age of 60 than in younger adults

      There is an unknown and very concerning risk, particularly among long-term users, of cancer and rapid spread (metasteses) of cancer among those who have cancer or un-detected cancer

     

    *see package inserts for injectible GH, and:

    *Blackman MR, Sorkin JD, Munzer T, et al. Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. Journal of the American Medical Association 2002;288:2282–2292.


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GH Likely Accelerates Aging and Shortens Life Span (It Certainly Does in Mice)

and

There's No Reputable Evidence That GH Enahnces Longevity or Increases Life Span

 

  1. Alexander B. A Drug's Promise (or Not) of Youth. Los Angeles Times, July 9, 2006.

  2. Bonkowski MS, Rocha JS, Masternak MM, Al Regaiey KA, Bartke A. Targeted Disruption of Growth Hormone Receptor Interferes with the Beneficial Actions of Calorie Restriction. Proceedings of the National Academy of Sciences. 2006;103:7901-7905.

  3. Bartke A. Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging. Endocrinology. 2005; 146:3718-3723.


SF Fitness Examiner

Adverse side effects of steroids [and HGH] are real - and often fatal

 

Jim Evans is a 41-year veteran of the health and fitness industry and internationally recognized fitness consultant.June 3, 8:33 PM " 

Let me tell you a story about a former world-ranked boxer. He’s legless now and confined to a wheelchair. He’s living proof of the dangers of steroids.
There are others who are not so lucky, because they’re dead.
This man once ranked among the world’s top 20 heavyweights. However, he tried to gain an edge – more size and strength – by using anabolic steroids. He got bigger. He got stronger. But inside he was destroying himself. Before long he had several heart attacks, blood clots, and gangrene in his limbs. By the end of 1987, his legs had been amputated because of the effects of anabolic steroids.
Today he’s confined to a wheelchair.
How do I know this? That person is me – and I can tell you from experience – steroids are not worth the risk! Please stay off of steroids, no matter how much you want to win, or hoe much someone tempts you to use them. "Robert Hazelton (Bob Hazelton is a former professional boxer who once fought George Foreman for the Heavyweight Title) 

Young people everywhere, men and women alike – many of them athletes or athletic “wannabes” - are using anabolic steroids under the false premise that any potential adverse side effects will happen “to someone else” but not to them. There is an epidemic of steroid use in this country that is quietly being shoved under the rug because parents, coaches, and school administrators refuse to face the fact that steroids are dangerous – and illegal – drugs.

But nothing has really changed.
More than 15 years ago Dr. Robert Voy, the former chief medical officer for the U.S. Olympic Committee and former medical review officer for the NFL Players Association, estimated that 10-25% of high school preps were using steroids. “Kids as young as 12 and 13 are taking steroids,” said Voy, one of the leading experts on performance enhancing drug abuse. “And in my experience, many parents of steroid-using young athletes are completely oblivious of what their child is doing.”

USA Today reported  as far back as December 1990 that steroid use among college football players was as high as 29%. The mean projected rate of use among men was 14.7% and 5.9% for women at that time.
The steroid problem is even worse today but, still, there is no testing of high school athletes, and while California’s Governor Arnold Schwarzenegger – an admitted steroid user in his competitive bodybuilding days – now condems their use, the fact remains that, if he had not used steroids, Schwarzenegger would probably not have achieved his bodybuilding and movie fame and would likely not be governor today.

And every youngster in America knows it. Schwarzenegger’s belated, after-the-fact condemnation of steroids – and the same can be said of Minnesota’s former governor Jesse “The Body” Ventura – is, perhaps, the worst kind of example of the classic proverb “do as I say, not as I do.”
Professional wrestling (let’s call it what it really is – “wrassling”) has largely built its reputation on oversized caricatures on steroids.

Yet, the sport – let’s call it physical entertainment – has experienced more than 65 deaths  (“Behind fund façade, professional wrestling sees 65 deaths in 7 years, “Jon Swartz, USA Today, March 12, 2004) largely attributed to the abuse of steroids and human growth hormone (HGH). Accoring to Keith Pinckard, a medical examiner in Dallas who has followed wrestling fatalities, professional wrasslers are more than 12 times more likely to die of heart disease than other Americans 25-44. Mike “Road Warrior Hawk” Hegstrand, Richard “Ravishing Rick Rude” Rood, Curt Henning, Davey Boy Smith, and “Flyin’” Brian Pillman, are just a few of the recent wrassling casualties attributed in part to steroid abuse. This author knew some of these athletes personally and witnessed their gradual decline.

Of course, we don’t often hear about the effects of steroid abuse among average people who are not famous. So, try these on for size:
• Michael Keys, 17, of Mount Clemens, Michigan, put a gun to his head and pulled the trigger in a classic case of “roid rage. Key had been using steroids for just a few months, and the chemical imbalance drove him into a suidal rage within 30 seconds of experiencing the trivial annoyance of not being able to open the door to his car, frozen from the icy out door temperatures that day. (People Magazine)
• Benji Ramirez, 17, of Ashtabula, Ohio, collapsed during football practice of a heart attack after a routine tackling drill. The county coroner concluded that steroids had contributed to his death. Many of his friends and classmates – and even his parents - knew that he was on steroids but said nothing – until after his death. (“The Death of an Athlete,” Rick Telander and Merrell Noden, Sports Illustrated) 
• Kirk Vinchattle, 22, of Boone, Iowa, suffered an almost-fatal aneurism and lost more than 2 pints of blood after his blood pressure spiked to 240/140 caused from using steroids for just 12 weeks. “I’d rather play Russion Roulette,” says Vinchattle after several days in intensive care. “It’s safer.
”
Former NFL All-Pro Lyle Alzado died of brain cancer at 39 after a long history of steroid and HGH abuse. During his career he suffered from numerous bouts of “roid rage” both on and off the field. At one time his cholesterol count was over 400, and a plastic surgeon twice removed baseball-sized lumps from his buttocks from where he had injected himself over the years. Before he died Alzado is quoted as saying, “Whoever is doing this stuff, if you stay on it too long, or maybe if you get on it at all, you’re going to get something bad from it. It is a wrong thing to do. If you’re on steroids or human growth hormone, stop. I should have.” (“I’m Sick and I’m Scared,” by Lyle Alzado as told to Shelley Smith, Sports Illustrated, July 8, 1991). Somehow that says it all. 

Growth Hormone Abuse May Boost Diabetes Risk

Friday, March 9, 2007; 6:00 PM

Copyright © 2007 ScoutNews, LLC. All rights reserved.

FRIDAY, March 9 (HealthDay News) -- People who use growth hormone to improve their athletic performance may be at risk of developing diabetes, say the authors of a case study involving a 36-year-old professional bodybuilder.

The man came to a hospital for emergency treatment of chest pain. He told doctors that he'd lost 88 pounds in 12 months and had experienced excessive thirst, appetite and urination during that time.

The bodybuilder said he'd used anabolic steroids for 15 years and artificial growth hormone for the previous three years. A year after starting to use artificial growth hormone, the man started taking insulin to counter the effects of high blood sugar.

However, he stopped taking insulin after he had a few episodes of low blood sugar while at the gym.

Tests conducted at the hospital showed that the man had very high blood sugar, his liver was inflamed, his kidneys were enlarged, and he was dehydrated. Doctors diagnosed him with diabetes and gave him intravenous fluids as well as gradually increasing amounts of insulin over five days.

His symptoms cleared up. Doctors told him he was no longer diabetic, and he was discharged from hospital.

The report authors said they believe this is the first reported cases of diabetes associated with the use of high-dose growth hormone. They urged anyone taking high doses of growth hormone to regularly check their blood sugar levels.

The study is in the British Journal of Sports Medicine.


Growth hormone to boost athletic performance risks diabetes

Use of growth hormone to boost athletic performance can lead to diabetes, reports a study published ahead of print in the British Journal of Sports Medicine.

The study reports the case of a 36-year-old professional body-builder who required emergency care for chest pain.


This press release issued by Eurekalert says that he had lost 40 kg in 12 months, during which he had also experienced excessive urination, thirst, and appetite.

He admitted to using anabolic steroids for 15 years and artificial growth hormone for the past three. He had also taken insulin, a year after starting on the growth hormone.

This was done to counter the effects of high blood sugar, but he had stopped taking it after a couple of episodes of acute low blood sugar (hypoglycaemia) while at the gym.


Tests revealed that his liver was inflamed, his kidneys were enlarged and that he had very high blood sugar. He was also dehydrated, and diagnosed with diabetes.

He was given intravenous fluids and gradually increasing amounts of insulin over five days, after which he was discharged. His symptoms completely cleared up, and he was no longer diabetic.


The use of growth hormone has steadily risen among amateur athletes and bodybuilders all round the world, say the authors, because it is easy to buy online and difficult to detect in screening tests—unlike anabolic steroids.


The authors believe that this is the first reported case of diabetes associated with the use of high dose growth hormone, and urge anyone taking high doses to regularly check their blood sugar levels.


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